fbpx Laboratory of Experimental and Translational Immunology | Intercollegiate Faculty of Biotechnology UG&MUG

Laboratory of Experimental and Translational Immunology | Intercollegiate Faculty of Biotechnology UG&MUG

Laboratory of Experimental and Translational Immunology

Last modified: 
2020, January 8 - 8:48am

PROFILE

We aim to understand immunological mechanisms which may influence response to antigen in the skin, with particular interest in atopic dermatitis. Given the importance of the epidermal barrier in the disease we also try to understand its role in the pathogenesis and response to allergens and pathogens. While we focus predominantly on the skin disease as a model body barrier dysfunction, we also investigate communication and antigen presentation in other conditions where immunological mechanism are dysregulated.

Scientific interests:

  •  communication between cells during immune responses via secreted extracellular vesicles
  •  epidermal barrier in health and disease
  •  mechanisms of allergic inflammation
  •  pathways of antigen presentation
  • novel immunotherapy approaches

Laboratory website: www.dgo.ug.edu.pl

dgo

RESEARCH TEAM

Laboratory of Experimental and Translational Immunology

Intercollegiate Faculty of Biotechnology UG&MUG
Abrahama 58 Street, 80-307 Gdańsk, Poland

DGO

Head: DSc. Danuta Gutowska-Owsiak [link]
tel.: +48 58 523 6433 [e-mail]

List of Employees and PhD students:

PhD Lilit Hovhannisyan
+48 58 523 6319 [e-mail]
PhD Joanna Frąckowiak
+48 58 523 6319 [e-mail]

MSc Adrian Kobiela

PUBLICATIONS

  1. Yi-Ling Chen, Tomas Gomes , Clare S. Hardman, Felipe A. Vieira Braga , Danuta Gutowska-Owsiak, Maryam Salimi, Nicki Gray, David A. Duncan , Gary Reynolds, David Johnson, Mariolina Salio, Vincenzo Cerundolo, Jillian L. Barlow, Andrew N.J. McKenzie, Sarah A. Teichmann, Muzlifah Haniffa, Graham Ogg. DC during acute sterile skin inflammation. Journal of Experimental Medicine 2020,(w druku) (doi: 10.1084/jem.20190811)
     
  2. Chen Yi-Ling, Gutowska-Owsiak Danuta, Hardman Clare S., Westmoreland Melanie, MacKenzie Teena, Cifuentes Liliana, Waithe Dominic, Lloyd-Lavery Antonia, Marquette Allison, Londei Marco, Ogg Graham. Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis. Science Translational Medicine 2019, 11 (515): pii: eaax2945 (doi: 10.1126/scitranslmed.aax2945)
     
  3. Gutowska-Owsiak Danuta, Bernardino de La Serna Jorge, Fritzsche Marco, Naeem Aishath, Podobas Ewa I., Leeming Michael, Colin-York Huw, O’Shaughnessy Ryan, Eggeling Christian, Ogg Graham S. Orchestrated control of filaggrin–actin scaffolds underpins cornification. Cell Death & Disease 2018, 9: 412 (doi: 10.1038/s41419-018-0407-2)