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Laboratory of Experimental and Translational Immunology

Last modified: 
2021, July 23 - 11:42am

PROFILE

We aim to understand immunological mechanisms which may influence response to antigen in the skin, with particular interest in atopic dermatitis. Given the importance of the epidermal barrier in the disease we also try to understand its role in the pathogenesis and response to allergens and pathogens. While we focus predominantly on the skin disease as a model body barrier dysfunction, we also investigate communication and antigen presentation in other conditions where immunological mechanism are dysregulated.

Scientific interests:

  •  communication between cells during immune responses via secreted extracellular vesicles
  •  epidermal barrier in health and disease
  •  mechanisms of allergic inflammation
  •  pathways of antigen presentation
  • novel immunotherapy approaches

Laboratory website: www.dgo.ug.edu.pl

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RESEARCH TEAM

Laboratory of Experimental and Translational Immunology

Intercollegiate Faculty of Biotechnology UG&MUG
Abrahama 58 Street, 80-307 Gdańsk, Poland

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Head: Danuta Gutowska-Owsiak, MD, PhD, DSc 
Professor at the University of Gdańsk
 [link]

tel.: +48 58 523 6433 [e-mail]

List of Employees and PhD students:

PhD Lilit Hovhannisyan
+48 58 523 6319 [e-mail]
PhD Joanna Frąckowiak
+48 58 523 6319 [e-mail]

MSc Adrian Kobiela

PROJECTS

Project title Project manager Source of financing Amount Years
Smart antigen provision for efficient induction of allergen tolerance Danuta Gutowska-Owsiak NCN Sonata BIS 9 3 824 800 zł 2020-2025
ArtExo: Artificial Exosomes For T-cell activation (collaborative grant with Prof. Jonathan Heddle) Danuta Gutowska-Owsiak FNP 1 000 000 zł 2020-2022
Keratinocyte-derived exosomes in induction of allergy and tolerance to environmental allergens -equipment grant Danuta Gutowska-Owsiak FNP 904 050 zł 2017-2022
Targeted exosome-mediated crosstalk between epithelial and antigen presenting cells for effective immunity at barrier sites ​ ​ ​  Danuta Gutowska-Owsiak NCN – Polonez 3 946 464 zł 2017-2019
Keratinocyte-derived exosomes in induction of allergy and tolerance to environmental allergens Danuta Gutowska-Owsiak FNP – First TEAM 2 2 200 000 zł 2017-2020

 

 

PUBLICATIONS

  1. Gutowska-Owsiak Danuta, Podobas Ewa I., Eggeling Christian, Ogg Graham S., de la Serna Jorge Bernardino. Addressing differentiation in live human keratinocytes by assessment of membrane packing order. Frontiers in Cell and Developmental Biology 2020, 8: 573230 (doi: 10.3389/fcell.2020.573230)
     
  2. Nedoszytko Bogusław, Reszka Edyta, Gutowska-Owsiak Danuta, Trzeciak Magdalena, Lange Magdalena, Jarczak Justyna, Niedoszytko Marek, Jablonska Ewa, Romantowski Jan, Strapagiel Dominik, Skokowski Jarosław, Siekierzycka Anna, Nowicki Roman J, Dobrucki Iwona T., Zaryczańska Anna, Kalinowski Leszek. Genetic and epigenetic aspects of atopic dermatitis. International Journal of Molecular Sciences 2020, 21:6484 (doi:10.3390/ijms21186484)
     
  3. Chen Yi-Ling, Gomes Tomas, Hardman Clare S., Vieira Braga Felipe A., Gutowska-Owsiak Danuta, Salimi Maryam, Gray Nicki, Duncan David A., Reynolds Gary, Johnson David, Salio Mariolina, Cerundolo Vincezo, L. Barlow Jilian L., McKenzie Andrew N.J., Teichmann Sarah A., Haniffa Muzlifah, Ogg Graham.  DC during acute sterile skin inflammation. Journal of Experimental Medicine 2020, 217 (3): e20190811 (doi: 10.1084/jem.20190811)
     
  4. Chen Yi-Ling, Gutowska-Owsiak Danuta, Hardman Clare S., Westmoreland Melanie, MacKenzie Teena, Cifuentes Liliana, Waithe Dominic, Lloyd-Lavery Antonia, Marquette Allison, Londei Marco, Ogg Graham. Proof-of-concept clinical trial of etokimab shows a key role for IL-33 in atopic dermatitis pathogenesis. Science Translational Medicine 2019, 11 (515): pii: eaax2945 (doi: 10.1126/scitranslmed.aax2945)
     
  5. Gutowska-Owsiak Danuta, Bernardino de La Serna Jorge, Fritzsche Marco, Naeem Aishath, Podobas Ewa I., Leeming Michael, Colin-York Huw, O’Shaughnessy Ryan, Eggeling Christian, Ogg Graham S. Orchestrated control of filaggrin–actin scaffolds underpins cornification. Cell Death & Disease 2018, 9: 412 (doi: 10.1038/s41419-018-0407-2)